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In the session on Crystal Growth at the 2023 meeting of the American Crystallographic Association in Baltimore, I presented Syed Aslam’s results of applying a Definitive Screening Design to the problem of growing larger RNA crystals. This work builds on the work by Barat Venkataramany and many other lab members, many of who were trained by Francis Acquah. We are applying these designs with guidance from Profess Charlie Carter Jr. This talk generated a lot of excitement and some useful suggestions from the audience. The slides and sample spreadsheet are located here. The libary will be expanded shortly.